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. 2020 Oct 29;11:567899. doi: 10.3389/fphys.2020.567899

FIGURE 1.

FIGURE 1

Crystallographic active sites of TMA lyase CutC/D and FMO3 with chemical structures of current known inhibitors. (A) Chemical structures of substrates and inhibitors of TMA lyase (Wang et al., 2015). (B) Choline bound to TMA lyase showing key binding interactions with active site amino acid residues that occur upon activation PDB 5AOU. (C) Chemical structures of dietary indole condensation products shown to be FMO3 inhibitors (Cashman et al., 1999). (D) Reactive enzymatic intermediates and key interactions with active site amino acid residues with TMA bound to FMO3 PDB 2GV8.