TABLE 1.

List of DEGs genes commonly representing prostate lineage markers and other markers related to prostate diseases along with their expression levels in AUB-PrC cells relative to their corresponding tissue counterparts in unaffected and tumor samples.

Markers	DEGs gene symbols	DEGs gene names	AUB-PrC cells vs. Tissues
			Unaffected samples		Tumor samples
			FC (log2)	p-adj	FC (log2)	p-adj
Basal epithelial	KRT5	Keratin 5	4.81	0.00034	4.77	0.00034
	KRT14	Keratin 14	5.7	1.51E-09	4.37	6.16E-06
	TP63	Tumor protein p63	2.32	0.07827	2.96	0.01257
	NKX3.1	NK3 Homeobox 1	–3.3	0.00118	–2.9	0.00498
Luminal epithelial	KRT8	Keratin 8	1.48	0.16463	2.99	0.00043
	KRT13	Keratin 13	2.78	0.40733	5.12	0.05105
	KRT18	Keratin 18	1.04	0.40985	2.35	0.01291
Intermediate epithelial	KRT19	Keratin 19	3.57	0.01804	2.99	0.04917
Cadherins	CDH1	E-cadherin	1.55	0.27936	2.05	0.09614
	CDH2	N-cadherin	–5.08	0.0475	–4.34	0.00446
Prostate cancer related	AR	Androgen receptor	–3.12	0.01436	–2.81	0.02722
	VIM	Vimentin	–1.99	0.25782	–1.05	0.58212
	CD44	CD44 Molecule	2.27	0.00253	3.22	4.37E-06
	FOXA1	Forkhead Box A1	0.92	0.58522	1.19	0.39047
	TWIST1	Twist Family BHLH Transcription Factor 1	–2.06	0.37524	–4.25	0.01980
	IL6	Interleukin 6	–7.78	0.00111	–10.92	9.39E-07
	TMPRSS2	Transmembrane Serine Protease 2	–2.90	0.08178	–4.22	0.00371
	ERG	ETS Transcription Factor ERG	–3.40	2.49E-05	–3.27	4.73E-05
Growth factors	FGF10	Fibroblast Growth Factor 10	–9.38	9.95E-05	–9.55	6.35E-05
	FGFR1	Fibroblast growth factor receptor 1	–2.61	0.00081	–3.33	7.76E-06
	FGF2	Basic fibroblast growth factor (β-FGF)	–3.44	0.00076	–3.05	0.00242
	EGFR	Epidermal growth factor receptor	1.40	0.29082	2.18	0.04582
	EGF	Epidermal growth factor	0.84	0.77265	–1.77	0.41791
	NTF3	Neurotrophin-3	–6.68	0.00198	–8.20	0.00072

DEG, differentially expressed gene; FC, fold change.