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Left, IHC staining showed the expressions of MMP-13, IL-6 and Col-10 in articular cartilage at week 6 and 12 post-treatment. Scale bar, 100 μm. Right, quantification of cells expressing MMP-13, IL-6 and COL10A1 in cartilage at the indicated time points. *P < 0.05, **P < 0.01, ***P < 0.001, n = 5–6 animals per group.
