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. 2020 Oct 29;11:571372. doi: 10.3389/fphys.2020.571372

FIGURE 1.

FIGURE 1

Differences in body mass, tibia length, and whole knee joint histology scores. There was a significant effect of age (p < 0.05) on body mass in both Strain 13 and Dunkin Hartley guinea pigs (A). Dunkin Hartley guinea pigs were significantly heavier than Strain 13 guinea pigs. 15 mo Dunkin Hartley guinea pigs tended to be larger than their 5 mo counterparts (p = 0.0560), while 15 mo Strain 13 guinea pigs were significantly (p < 0.05) larger than 5 mo Strain 13 guinea pigs. However, there was a significant age-related increase in tibia length in Strain 13 guinea pigs (p < 0.05) (B). There was a significant effect of age and strain (p < 0.05) on whole joint histology scores. Dunkin Hartley guinea pigs displayed a significant increase at 9 and 15 mo in OA severity while Strain 13 guinea pigs only displayed a significant increase at 15 mo (C). *denotes p < 0.05 compared to 5 mo. *denotes p < 0.05 compared to 5 mo of the same strain; t denotes p < 0.10 compared to 5 mo of the same strain.