Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 29;11:573372. doi: 10.3389/fphys.2020.573372

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Lawrence, Willard, Cochran, Matchett and Kornbluth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Structure/function of NKLAM protein. The RING1-IBR-RING2 (RBR) domain has the ubiquitin ligase activity. RING2 contains the highly conserved, active site catalytic cysteine (C302), which is the defining feature of this family of RBR ligases. In addition to the two transmembrane (TM) domains, the N- and C-terminal ends of NKLAM are intrinsically disordered regions (IDR). Bioinformatic analysis using the DEPICTER server indicate the possible roles of the IDR in protein, DNA, and RNA binding.