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. 2020 Oct 29;11:600290. doi: 10.3389/fphys.2020.600290

FIGURE 2.

FIGURE 2

The combination of COPD and hypercapnia leads to a reduced specific force generation capacity. (A) While normo and hypercapnia per se, and normocapnic (NC) murine COPD associate with a preserved specific force-generation capacity, the combination of murine COPD and hypercapnia (HC) leads to a significant reduction of specific force, which is a surrogate of intrinsic contractile properties of individual fibers (n = 4), ***p < 0.001. (B) RNA seq analysis of EDL muscles obtained from normo and hypercapnic murine COPD model demonstrate a significant hypercapnia-induced downregulation of extracellular matrix (ECM) receptor interactions term and multiple genes. Sequencing was generated by an Ion Torrent Ion S5 plus system, Thermo Fisher scientific (n = 4), *p < 0.05; #p > 1.5-fold change. For details about the animals details including genetic backgrounds and hypercapnia setup, see our recent publications (Jaitovich et al., 2015; Balnis et al., 2020a,b,c; Korponay et al., 2020). Presented data is original and thus has not been previously reported.