TABLE 2.
Biosurfactants reported recently with anti-biofilm activities.
| Class | Source microorganism | Pathogen strains | Effect on biofilm | Dose | References |
| Lipopeptide biosurfactants (LPBs) | Acinetobacter junii | Biofilm of Staphylococcus aureus, Proteus mirabilis, and Pseudomonas aeruginosa | Biofilm disruption 35, 10, and 32%, respectively Biofilm disruption 52, 31, and 70%, respectively |
1250 μg/ml 2500 μg/ml |
Ohadi et al., 2020 |
| Lipopeptide | Beauveria bassiana | Microsporum canis | 25.76% biofilm eradication | 1.95 μg/ml | Abdel-Aziz et al., 2020 |
| Lipopeptide surfactin-C15 | B. subtilis #309 | Candida albicans | 85% inhibition to biofilm formation | 960 μg/ml | Janek et al., 2020 |
| Lipopeptide surfactin | Bacillus safensis F4 | Staphylococcus epidermidis | 80% anti-adhesive activity | 6.25 mg/ml | Abdelli et al., 2019 |
| Lipopeptide pontifactin | Pontibacter korlensis strain SBK-47 | Bacillus subtilis, Staphylococcus aureus, Salmonella typhi, and Vibrio cholerae | 99% anti-adhesive activity | 2 mg/ml | Balan et al., 2016 |
| Lipopeptide | Bacillus subtilis AC7 | Candida albicans | Reduced adhesion up to 67–69% and biofilm formation up to 56–57% | 2 mg/ml | Ceresa et al., 2016 |
| Glycolipoprotein | Acinetobacter indicus M6 | Methicillin-resistant Staphylococcus aureus | 82.5% removal of biofilm | 500 μg/ml | Karlapudi et al., 2020 |
| Glycolipid | Burkholderia sp. WYAT7 | Staphylococcus aureus | 41% inhibition to biofilm formation 79% inhibition to biofilm formation |
1 mg/ml 2 mg/ml |
Ashitha et al., 2020 |
| Rhamnolipids | Pseudomonas aeruginosa MN1 | Streptococcus mutans | Dissociation of 67% of the preformed biofilm | 12.5 mg/ml | Abdollahi et al., 2020 |
| Rhamnolipids | Burkholderia thailandensis E264 | Streptococcus oralis, Actinomyces naeslundii, Neisseria mucosa, and Streptococcus sanguinis | 90% inhibition of S. sanguinis biofilm 70% inhibition of S. oralis biofilm 70% inhibition of N. mucosa biofilm 50% inhibition of A. naeslundii biofilm |
0.39 mg/ml 0.78 mg/ml 6.25 mg/ml 12.5 mg/ml |
Elshikh et al., 2017 |
| Exopolysaccharides | Pandorea pnomenusa MS5 | Burkholderia cepacia | Inhibit Burkholderia cepacia biofilm formation | 0.25 mg/ml | Sacco et al., 2019 |