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. 2020 Nov 10;6(5):1423–1435. doi: 10.1016/j.bioactmat.2020.10.020

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© 2020 [The Author/The Authors]

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Preparation and characterization of SAPEG-MPDA@SPIO/DOX/Fe³⁺ NPs. (A) Schematic illustration of the preparation of SAPEG-MPDA@SPIO/DOX/Fe³⁺ NPs. (B) TEM images of SPIO NPs. (C) TEM images of SAPEG-MPDA@SPIO NPs. (D) SEM images of SAPEG-MPDA@SPIO NPs. Particle size distribution (E) and FTIR spectra (F) of MPDA@SPIO, PEG-MPDA@SPIO and SAPEG-MPDA@SPIO NPs. (G) The amount of Fe³⁺ chelated by PEG-MPDA@SPIO NPs and SAPEG-MPDA@SPIO NPs. (H) The DOX encapsulation efficiency (EE) and drug loading capability (DL) of SAPEG-MPDA@SPIO/Fe³⁺ NPs. (I) The DOX release profiles of SAPEG-MPDA@SPIO/DOX/Fe³⁺ NPs. (ns is non-significant, n = 3).