Table 1.
Top 5 GO Terms and KEGG Pathways.
| Up-regulated DEGs | |||||
|---|---|---|---|---|---|
| Category | Term | Count | % | P-Value | FDR |
| GOTERM_BP_DIRECT | immune response | 65 | 13.42975207 | 1.71E-30 | 2.98E-27 |
| GOTERM_BP_DIRECT | inflammatory response | 57 | 11.7768595 | 4.31E-26 | 7.48E-23 |
| GOTERM_BP_DIRECT | regulation of immune response | 37 | 7.644628099 | 8.92E-22 | 1.55E-18 |
| GOTERM_BP_DIRECT | Chemotaxis | 25 | 5.165289256 | 1.32E-14 | 2.29E-11 |
| GOTERM_BP_DIRECT | innate immune response | 45 | 9.297520661 | 1.64E-14 | 2.85E-11 |
| GOTERM_CC_DIRECT | plasma membrane | 198 | 40.90909091 | 1.66E-21 | 2.22E-18 |
| GOTERM_CC_DIRECT | integral component of plasma membrane | 101 | 20.8677686 | 4.40E-21 | 5.88E-18 |
| GOTERM_CC_DIRECT | external side of plasma membrane | 36 | 7.438016529 | 1.46E-18 | 1.95E-15 |
| GOTERM_CC_DIRECT | Membrane | 112 | 23.14049587 | 1.39E-12 | 1.85E-09 |
| GOTERM_CC_DIRECT | cell surface | 46 | 9.504132231 | 4.83E-12 | 6.46E-09 |
| GOTERM_MF_DIRECT | transmembrane signaling receptor activity | 28 | 5.785123967 | 1.10E-11 | 1.62E-08 |
| GOTERM_MF_DIRECT | receptor activity | 25 | 5.165289256 | 2.37E-09 | 3.50E-06 |
| GOTERM_MF_DIRECT | peptide antigen binding | 9 | 1.859504132 | 3.80E-07 | 5.62E-04 |
| GOTERM_MF_DIRECT | non-membrane spanning protein tyrosine kinase activity | 10 | 2.066115702 | 2.31E-06 | 0.003414307 |
| GOTERM_MF_DIRECT | carbohydrate binding | 19 | 3.925619835 | 3.69E-06 | 0.005465935 |
| KEGG_PATHWAY | ll adhesion molecules (CAMs) | 31 | 6.404958678 | 2.77E-14 | 3.49E-11 |
| KEGG_PATHWAY | teoclast differentiation | 29 | 5.991735537 | 1.55E-13 | 1.97E-10 |
| KEGG_PATHWAY | emokine signaling pathway | 32 | 6.611570248 | 8.16E-12 | 1.03E-08 |
| KEGG_PATHWAY | matopoietic cell lineage | 22 | 4.545454545 | 1.65E-11 | 2.09E-08 |
| KEGG_PATHWAY | tigen processing and presentation | 20 | 4.132231405 | 8.16E-11 | 1.03E-07 |
| Down-regulated DEGs | |||||
| Category | Count | % | P-Value | FDR | |
| GOTERM_BP_DIRECT | epidermis development | 5 | 4.95049505 | 9.89E-04 | 1.402276079 |
| GOTERM_BP_DIRECT | anterior/posterior pattern specification | 4 | 3.96039604 | 0.008282332 | 11.19465957 |
| GOTERM_BP_DIRECT | regulation of endothelial cell migration | 2 | 1.98019802 | 0.030690865 | 35.91621507 |
| GOTERM_BP_DIRECT | surfactant homeostasis | 2 | 1.98019802 | 0.040712771 | 44.75213723 |
| GOTERM_BP_DIRECT | cell proliferation | 6 | 5.940594059 | 0.041472764 | 45.37368224 |
| GOTERM_CC_DIRECT | lateral plasma membrane | 3 | 2.97029703 | 0.030594477 | 29.96310402 |
| GOTERM_CC_DIRECT | apical plasma membrane | 5 | 4.95049505 | 0.06375991 | 53.00598794 |
| GOTERM_CC_DIRECT | ruffle membrane | 3 | 2.97029703 | 0.067032426 | 54.85469851 |
| GOTERM_CC_DIRECT | bicellular tight junction | 3 | 2.97029703 | 0.115507169 | 75.50857327 |
| GOTERM_CC_DIRECT | cytoplasmic vesicle | 4 | 3.96039604 | 0.121577153 | 77.36737309 |
| GOTERM_MF_DIRECT | actin binding | 6 | 5.940594059 | 0.015794288 | 17.88057551 |
| GOTERM_MF_DIRECT | sequence-specific DNA binding | 7 | 6.930693069 | 0.055854092 | 50.89357101 |
| GOTERM_MF_DIRECT | phosphatidylcholine 1-acylhydrolase activity | 2 | 1.98019802 | 0.056505636 | 51.31125112 |
| GOTERM_MF_DIRECT | Rho guanyl-nucleotide exchange factor activity | 3 | 2.97029703 | 0.06235964 | 54.92020291 |
| GOTERM_MF_DIRECT | quinone binding | 2 | 1.98019802 | 0.071360474 | 59.9920399 |
| KEGG_PATHWAY | GF signaling pathway | 3 | 2.97029703 | 0.023549806 | 23.63944894 |
| KEGG_PATHWAY | tabolic pathways | 10 | 9.900990099 | 0.037458967 | 35.08367142 |
| KEGG_PATHWAY | RH signaling pathway | 3 | 2.97029703 | 0.04905159 | 43.40214167 |
| KEGG_PATHWAY | flammatory mediator regulation of TRP channels | 3 | 2.97029703 | 0.055992696 | 47.90530816 |
| KEGG_PATHWAY | utamatergic synapse | 3 | 2.97029703 | 0.073050211 | 57.61895265 |