Table 1.
Summary of ventilatory parameters, therapeutic interventions, tomographic, and laboratory results.
| CASE 1 - 87-year-old woman | CASE 2 - 53-year-old man | |
|---|---|---|
| Comorbidities | Systemic Arterial Hypertension Dyslipidemia Hypothyroidism Senile dementia |
Class II obesity |
| Chronic use drugs | Losartan 50mg/day | No |
| Ventilatory parameters | Decreased positive end-expiratory pressure (PEEP), with ideal PEEP = 10 Compliance = 52 cmH2O Plateau pressure of 24 cmH2O Driving pressure of 14 cmH2O Inspiratory fraction of oxygen (FiO2) of 60% Pressure partial Oxygen (PaO2): PaO2/FiO2 = 126 |
Decreased positive end-expiratory pressure (PEEP), with ideal PEEP = 08 Compliance = 65 cmH2O Plateau pressure = 19 cmH2O Driving pressure = 11 cmH2O Inspiratory fraction of oxygen (FiO2) = 50% Pressure partial Oxygen (PaO2): PaO2/FiO2 = 132 |
| Pronation maneuver | Partial response - PaO2/FiO2 ratio of 191 | Adequate response - PaO2/FiO2 ratio = 270 |
| Admission Computed tomography | Diffuse and bilateral “opacities with ground-glass attenuation” Thickening of the pulmonary septum, suggestive of viral pulmonary infection |
Diffuse and bilateral “opacities with ground-glass attenuation”, suggestive of viral pulmonary infection |
| Admission laboratory tests | C Reactive Protein = 313 mg/L; D-dimer = 2014 μg/dL; Total leukocytes = 15,100/neutrophils = 1208 (8%) and lymphocytes = 604 (4%); Creatinine = 1.1 mg/dL |
C-Reactive Protein = 146 mg/L; D-dimer = 425 μg/mL (normal); Total leukocytes = 11,000/neutrophils = 550 (5%) and lymphocytes = 990 (9%). |
| Laboratory tests (24 hours before death) | C-Reactive Protein = 201 mg/dL; Leukocytes = 15,000/neutrophils = 2400 (16%) and lymphocytes = 1200 (8%); Creatinine = 2.65 mg/dL. |
C-Reactive Protein = 133 mg/dL; Leukocytes = 50,200/neutrophils = 3012 (6%) and lymphocytes = 3514 (7%). |
| Therapeutic drugs | Hydroxychloroquine 800 mg/day on the 1st day and 400 mg/day on the other days + Azithromycin 500 mg/day for 5 days; Oseltamivir 150 mg/day for 5 days Piperacillin + Tazobactam 18 mg/day |
Hydroxychloroquine 800 mg/day on the 1st day and 400 mg/day on the other days + Azithromycin 500 mg/day for 5 days; Oseltamivir 150 mg/day for 5 days; Ceftriaxone 2g/day |
| Invasive procedure | No | ECMO (Extracorporeal Membrane Oxygenation) |