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. 2020 Oct 14;22:885–899. doi: 10.1016/j.omtn.2020.10.007

Figure 7.

Figure 7

The Smad-Targeting siRNAs Effectively Inhibit BMP9-Induced Bone Matrix Mineralization while Enhancing BMP9-Induced Adipogenic Differentiation in BMSCs

The BMSCs stably expressing simSmad4, simSmad1458, simSmad4158, or siControl cells (BMSCs) were infected with AdGFP or AdBMP9. (A) At 10 days after infection, the cells were fixed and subjected to alizarin red S staining and oil red O staining (a, day 3; b, day 7). Representative images are shown. (B) Both alizarin red S stain and oil red O stain were dissolved and quantitatively measured. ∗∗p < 0.01, compared with the BMSC-siControl.