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. 2020 Nov 12;102:375–380. doi: 10.1016/j.ijid.2020.11.127

Table 2.

Comparative analysis of symptoms and comorbidities in hospitalized COVID-19 and 2009 influenza patients.

COVID-19 pandemic 2009 influenza pandemic
Characteristics Estimates(95% CI) Study No. Patient No. Estimates
(95% CI)
Study No. Patient No. p-value
Symptoms
Cough 57.99% (53.32–62.59) 56 14,717 85.31% (82.84–87.63) 82 20,710 < 0.0001
Fever 72.08% (63.27–80.13) 57 16,006 89.99% (87.64–92.13) 78 20,571 < 0.0001
Diarrhea 10.16% (7.23–13.51) 41 14,434 11.27% (9.63–13.01) 63 17,433 0.3897
Fatigue 30.20% (24.75–35.93) 34 6,875 48.20% (29.64–67.03) 16 4391 0.0965
Shortness of breath 32.89% (27.09–38.95) 54 14,211 49.19% (40.40–58.01) 25 5521 0.0249
Sore throat 9.48% (7.47–11.69) 34 8502 37.28% (32.00–42.70) 61 17,268 < 0.0001
Rhinorrhea 8.48% (6.02–11.28) 27 8040 38.57% (33.11–44.17) 55 15,997 < 0.0001
Myalgia/muscle pain 18.97% (14.23–24.20) 36 12,865 30.12% (24.68–35.84) 68 16,940 0.0242
Vomiting/nausea 8.67% (5.40–12.59) 27 13,174 24.27% (20.51–28.25) 52 12,846 < 0.0001
Comorbidity
Cardiovascular disease/ Hypertension 28.76% (22.91–34.99) 83 33,019 13.11% (10.84–15.55) 41 10,144 < 0.0001
Obesity 28.48% (19.04–38.94) 18 12,819 17.89% (13.40–22.86) 46 13,409 0.1081
Diabetes 16.38% (13.65–19.30) 89 33,407 11.12% (9.39–12.97%) 58 17,031 0.0120
Asthma 8.42% (6.69–10.32) 19 7732 16.09% (13.15–19.26) 53 16,034 0.0033
COPD 4.93% (3.78–6.21) 44 14,107 9.52% (7.09–12.24) 37 11,493 0.0003
Immunocompromised 4.39% (2.50–6.71) 29 9111 9.99% (8.30–11.82) 48 17,521 < 0.0001
Cancer/malignancy 4.75% (3.59–6.06) 40 23,815 5.76% (4.09–7.67) 25 6557 0.2906
Heart disease 12.89% (9.71–16.43) 43 13,876 8.66% (6.30–11.34) 28 7396 0.2249
Renal disease 8.10% (5.93–10.56) 56 26,016 4.90% (3.86–6.05) 35 9793 0.1676

COPD, chronic obstructive pulmonary disease.