Fig. 6.

Reduction in JMS-053 inhibition of PTP4A3 and ovarian cancer spheroid viability with the presence of albumin. (A) The IC₅₀ values for JMS-053 PTP4A3 inhibition in vitro with increasing concentrations of BSA. The mean values are indicated for the four or five independent observations, which are marked as black circles. Bars indicate S.D., and P = 0.015 as determined with one-way ANOVA with Dunnett’s test for comparisons involving multiple groups. (B) Increase in A2780 ovarian cancer spheroid survival with reduction of FBS concentrations. Blue circles = 10% FBS; red squares = 5% FBS; open black squares = 1% FBS; black diamonds = 0.5% FBS. N = 3, and bars = S.D.