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. 2020 Oct 29;11:590568. doi: 10.3389/fimmu.2020.590568

Figure 1.

Figure 1

Diet-induced obesity delays the onset and dampens the severity of clinical symptoms in Experimental Autoimmune Encephalomyelitis (EAE). (A) MRI imaging of 6-month-old male control and DIO mice. White arrows point to adipose tissue. (B) Body weight of 8-month-old control and DIO mice. (C) Schema of experimental design. C57BL/6 male mice were placed on 10% fat (CD) or 60% fat diet (HFD) for 6-7 months and induced with EAE. (D) EAE clinical score. (E) Percent of mice with EAE clinical scores of severity of at least 3 per day. n = 13–14/group; means from three separate experiments. Bar graphs depict mean ± SEM. Significance for differences in clinical scores were determine by Mann-Whitney ranking U test. ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.