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. 2020 Oct 29;8:582320. doi: 10.3389/fcell.2020.582320

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Copyright © 2020 Gubert, Kong, Uzungil, Zeleznikow-Johnston, Burrows, Renoir and Hannan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gastrointestinal parameters of mGlu5 KO mice. (A) Fecal water content as a percentage of difference between the initial total feces weight and the dry weight. (B) Fecal output, counting the number of fecal pellets expelled during 1 h. (C) Gastrointestinal transit time, using the non- absorbable red dye Carmine red and recording first appearance in the feces. (D) Gut permeability measured by 4 kDa fluorescein isothiocyanate (FITC)-dextran assay. (E) Macroscopic evaluation of intestine. (F) Cecum length, (G) cecum weight, and (H) colon length normalized by body weight, unpaired t-test. The plots show mean ± SEM (n = 6–7 for both WT and mGlu5 KO mice groups). *p < 0.05, **p < 0.01, ***p < 0.001, and ns p > 0.05.