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Schematic diagram of LRNA9884 in NF-kB/MIF axis regulation. In AKI, IL-1β triggers NF-kB signaling, which in turn upregulates LRNA9884 in the nucleus, and which binds on the promoter region of MIF genome therefore enhancing MIF transcription at genomic level. LRNA9884 will positively promote IL-1β/NF-κB signaling therefore further promoting the inflammatory response.
