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. 2020 Nov 10;218(2):e20192191. doi: 10.1084/jem.20192191

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© 2020 Maccari et al.

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Figure 6. — Impact of age, localization, and acute infections on FC T cell pool size in HDs. (A and B) Percentages of CD38⁺CD45RA⁺ FC DNTs among CD3⁺TCRαβ⁺ T cells and absolute numbers of CD38⁺CD45RA⁺ FC DNTs/µl in peripheral blood of HDs (n = 54 and n = 47, respectively) are shown in relation to donor age in years. Values determined in HD cord blood are depicted in red. Solid lines represent linear regression analyses. R² and P values are shown. (C) Example plots showing percentages and phenotypes of CD38⁺CD45RA⁺ FC DNTs in cord blood (CB; n = 3) compared with adult peripheral blood (PB; n = 10). (D) Percentages of CD38⁺CD45RA⁺ FC DNTs of CD3⁺TCRαβ⁺ T cells in HD PB (n = 54, age range the same as for A) compared with adult SLOs (n = 8) and adult bone marrow (BM; n = 4). Lines indicate medians. Statistical comparisons were performed using the Kruskal-Wallis test. ns, not significant; ***, P < 0.001. (E) Example plots showing percentages of CD38⁺CD45RA⁺ FC DNTs in one adult HD and one patient with acute EBV infection. (F) Summary plot depicting percentages of CD38⁺CD45RA⁺ FC DNTs of CD3⁺TCRαβ⁺ T cells in peripheral blood of HDs (n = 54) versus patients with acute EBV infection (n = 11) in relation to donor age.