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. 2020 Nov 10;218(2):e20192191. doi: 10.1084/jem.20192191

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© 2020 Maccari et al.

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Figure S3. — Small populations of CD4⁺ and CD8⁺ T cells share the FC T cell signature. (A) Number of significantly dysregulated genes (DEGs; adjusted P < 0.05) between the indicated comparisons by RNA sequencing analysis. Patient DNTs, CD8⁺ N+EDs, CD8⁺ LDs, and DNT-like CD8⁺ (CD8⁺CD28⁺CD57⁺) as well as HD CD8⁺ LDs were included. (B) Example FACS plots showing percentages and phenotypes of FC CD4⁺ and CD8⁺ T cells in one ALPS patient and one HD. Comparable results were generated in 9 ALPS patients and 20 HDs (data not shown). (C) Percentages of CD38⁺CD45RA⁺ cells of CD4⁺ T cells and of CD8⁺ T cells in peripheral blood (black symbols) and spleen (red symbol) of 13 ALPS patients. Lines indicate medians. (D) Representative histograms showing galectin 3 and pMYB expression in conventional and CD38⁺CD45RA⁺ T cells of one ALPS-FAS patient. Comparable results were generated in three ALPS patients.