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Control and CDK5RAP2Δ RPE1 cells labeled with SiR-DNA and imaged at 20× magnification. 8 × 2–µm z-stacks were acquired every 5 min. Image frames shown are maximum intensity projections at each time point. Playback is sped up 900× relative to real-time. Elapsed time shown is in hours:minutes, and scale bar is 10 µm. KO, knockout.
