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. 2020 Oct 23;23(11):101726. doi: 10.1016/j.isci.2020.101726

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Phenotypes Due to the Combined Deletion of Regions 4 and 6

(A) Underinflation of lungs is the cause of the death of most Tnf^del4del6/+/Tnfr1^+/− pups soon after birth. Tnf^del4del6/+/Tnfr1^+/− pups that survive develop IBD (B) and extremely severe arthritis (C).

(B) Immune cell infiltration in the cecum of a 20 day-old Tnf^del4del6/+/Tnfr1^+/− pup as seen by H&E staining.

(C) Dislocated and pannus-infiltrated ankle in the same animal as in (B).