Fig. 4.

Genetic ablation of PGAM5 sustains myocardial function after I/R injury. (A–C) Echocardiographic measurements performed after I/R injury. n = 6 mice per group. (D–I) Evaluation of mechanical properties of single, acutely isolated cardiomyocytes from I/R-treated mice. +dL/dt: maximal velocity of shortening; −dL/dt: maximal velocity of relengthening; TPS: time-to-peak shortening; TR90: time-to-90% relengthening. n = 70–80 cells from 2 mice per group. Experiments were repeated three times with similar results. Data are shown as the means ± SEM. *p < 0.05.