Table 4:

Studies investigating the relationship between pretreatment ADC and outcome after chemoradiation therapy in head and neck cancer

Reference	Year of Publication	No. of Patients	No. of Patients with OPSCC	HPV Status Available	High ADC Associated with
Kim et al15	2009	33	22	N	Poor outcome
Hatakenaka et al16	2011	57	22	N	Poor outcome
Ohnishi et al17	2011	64	30	N	Poor outcome
Srinivasan et al18	2012	20	11	N	Poor outcome
Nakajo et al19	2012	26	8	N	Better outcome
King et al20	2013	37	14	N	Poor outcome
Chawla et al21	2013	32	9	N	Poor outcome
Lambrecht et al22	2014	161	85	N	Poor outcome
Ng et al23	2016	69	37	N	Poor outcome
Noij et al24	2015	78	40	N	Poor outcome
Preda et al25	2016	57	11	Na	Poor outcome
Marzi et al26	2017	34	14	N/Yb	Poor outcome
Lombardi et al27	2017	47	19	N	Poor outcome
Martens et al28	2019	134	96	Y	Poor outcomec

Note:—N indicates no; Y, yes.

^aMinimum ADC value within the ROI.

^bOnly for the small cohort of patients with OPSCC.

^cMaximum ADC value within the ROI.