Fig 4.

Bar chart showing median, minimum, and maximum Lac concentrations in all patients with IDH gene mutations and WHO II and III gliomas (no WHO IV), comparing those with chromosomal losses of 1p and 19q with those with no chromosomal losses. We found a significant difference in Lac concentrations (P < .038, t test). However, if one compared WHO II with WHO III tumors with IDH gene mutations, there was no significant difference. This finding points toward IDH gene mutations and chromosomal losses as 2 contributing factors to changes in cell metabolism independent of WHO grade. LOH indicates loss of heterozygosity.