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. 2020 Nov 12;18(2):696–717. doi: 10.1007/s12015-020-10068-9

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© Springer Science+Business Media, LLC, part of Springer Nature 2020

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 1 — Three-dimensional (3D) modeling of neurodegenerative diseases. The overview of limitations, current progress and future direction in using human induced pluripotent stem cells (hiPSCs)-derived 3D cultures/cerebral organoids (COs) to model Alzheimer’s disease and other neurodegenerative diseases (created with BioRender.com).