Table 6.

Villani et al. 2016 version of the surveillance protocol for children (birth to age 18 years) with germline TP53 pathogenic variants.

Adrenocortical Carcinoma	Ultrasound of abdomen and pelvis every 3–4 months  Blood tests every 3–4 months: 17-OH-progesterone, total testosterone, dehydroepiandrosterone sulfate, androstenedione  24 h urine cortisol, if feasible
Brain tumor	Annual brain MRI
Soft tissue and bone sarcoma	Annual rapid whole-body MRI
Leukemia or lymphoma	Blood tests every 3–4 months*: complete blood count, erythrocyte sedimentation rate, lactate dehydrogenase
General assessment	Complete physical examination every 3–4 months, including anthropometric measurements plotted on a growth curve (with particular attention to rapid acceleration in weight or height), signs of virilization (pubic hair, axillary moisture, adult body odor, androgenic hair loss, clitoromegaly, or penile growth) and full neurological assessment  Prompt assessment with primary care physician for any medical concerns

*Serial specimens obtained at the same time of day and processed in the same laboratory.