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. 2020 Oct 29;11:580897. doi: 10.3389/fphar.2020.580897

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Copyright © 2020 Luo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolism of PUFAs by CYP enzymes. (A) A simplified cascade of PUFAs discussed in this paper. AA, arachidonic acid; LA, linoleic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; CYP, cytochrome P450; sEH, soluble epoxide hydrolase; DHET, dihydroxyeicosatrienoic acid; DiHOME, dihydroxy octadecamonoeneoic acid; DiHETE, dihydroxyeicosatetraenoic acid; DiHDTE, dihydroxydocosatetraenoic acid; EET, epoxyeicosatrienoic acid; EpOME, epoxyoctadecamonoeneoic acid; EEQ or EpETE, epoxyeicosatetreaenoic acid; EDP or EpDPE, epoxydocosapentaenoic acid; HDoHE, hydroxydocosahexaenoic acid; HEPE: hydroxyeicosapentaenoic acid; HETE, hydroxyeicosatetraenoic acid; HODE, hydroxyoctadecadienoic acid; mEH, microsomal epoxide hydrolase; sEH, soluble epoxide hydrolase. The metabolites are from the fatty acids in the same color. (B) The chemical structures of PUFAs and the representative metabolites.