TABLE 1.

Examples of some cancers associated with cytochrome P450 enzymes.

CYPs	Polymorphism	Cancers	population	References
CYP1A1	T3801C	Cervical cancer	Asians	Wu et al., 2013
	(rs4646903)		Caucasians and Asians	Ding et al., 2018
	and/or		Indians	Jain et al., 2017
	A2455G		Mexican	Juarez-Cedillo et al., 2007
	(rs1048943)		Chinese	Li et al., 2016
	—		Caucasians	Wang et al., 2017
	C2453A	Lung cancer	Egyptian	Ezzeldin et al., 2017; Gallegos-Arreola et al., 2008
			Mexican
	—	Laryngeal squamous cell carcinoma	Caucasian	Gajecka et al., 2005
		Thyroid cancer	Middle eastern	Siraj et al., 2008
		Cervical cancer	Northeast Thai	Wongpratate et al., 2020
	T3205C	Breast cancer	Indians	Singh et al., 2007
	(rs1800031)	Endometrial cancer	Caucasian	Hirata et al., 2008
	—	Cervical cancer	Northeast Thai	Wongpratate et al., 2020
CYP1A2	rs762551	Lung cancer	Caucasians	Bu et al., 2014
		Breast cancer	Jordanian	Al-Eitan et al., 2019
CYP1B1	rs1056827	Endometrial cancer	Chinese	Zhu et al., 2011
		Laryngeal cancer	Chinese	Yu et al., 2015
CYP2A6	CYP2A6*4	Lung cancer	Japanese	Raunio et al., 2001
	and		Caucasian
	CYP2A6*5		—
CYP2C9	rs1799853	Head and neck squamous cell carcinoma	Indian	Yadav et al., 2014
	rs1799853	Non-small cell lung cancer	Caucasians	Sausville et al., 2018
	and
	rs1057910
CYP2C19	CYP2C19*2	Bladder cancer	German	Brockmoller et al., 1996
	(rs4244285)
	CYP2C19*3	Lung cancer	Chinese	Yan et al., 2014
	—		Japanese	Tsuneoka et al., 1996
		Breast cancer	Chinese	Gan et al., 2011
		Digestive system cancer	East Asians	Zhou et al., 2013
	CYP2C19*17	Breast cancer	German	Justenhoven et al., 2009
	(rs12248560)
CYP2D6	CYP2D6*1A	Bladder cancer	Egyptian	Abdel-Rahman et al., 1997
	CYP2D6*3	Lung cancer	African-Americans	London et al., 1997
	CYP2D6*4
	CYP2D6*5
	and CYP2D6*16
	CYP2D6*4	Childhood acute leukemia	Italian	Ferri et al., 2018
		Malignant melanoma	British	Strange et al., 1999
	CYP2D6*3	Prostate cancer	Danish	Wadelius et al., 1999
	and
	CYP2D6*4
	CYP2D6*10	Hepatocellular carcinoma	Chinese	Zhou et al., 2016
	(rs10655852)
CYP3A4	CYP3A4*1B	Leukemia	Chinese	Zheng et al., 2018
	CYP3A4*1G	Breast cancer	Chinese	Liu et al., 2019
	(rs2242480)
	CYP3A4 A392G	Prostate cancer	Caucasians	He et al., 2014