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. 2020 Oct 29;10:565031. doi: 10.3389/fonc.2020.565031

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Copyright © 2020 Timbergen, Boers, Vriends, Boers, van IJcken, Lavrijsen, Grünhagen, Verhoef, Sleijfer, Smits, Gribnau and Wiemer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Supervised hierarchical clustering based on differentially methylated regions (DMRs) between S45F and T41A mutated DTF tumors together with clinicopathological features: sex, tumor site, age, and tumor size. The heat map depicts the methylation in 354 DMRs, including all fold-changes and excluding DMRs present on sex chromosomal regions, in S45F and T41A DTF samples. The cluster tree on top indicates distinct subgroups of DTF samples. Grouping, however, is not based on CTNNB1 mutation type (T41A or S45F) nor on clinicopathological parameters such as sex, tumor site, age, or tumor size.