Table 1.
Pain related genes regulated by capsaicin.
| S.No. | Gene symbol | LogFC | Regulation | Nociception1 | Hypersensitivity1 | Analgesia1 |
|---|---|---|---|---|---|---|
| 1. | Ctss | 0.646 | Up | No effect | Increase | N.T |
| 2. | Nmu | 0.509 | Up | Increase | N.T | N.T |
| 3. | Iapp | -2.469 | Down | Increase | N.T | N.T |
| 4. | Lpar3 | -1.834 | Down | No effect | Increase | N.T |
| 5. | Trpv1 | -1.581 | Down | Increase | Increase | N.T |
| 6. | Kcnk2 | -1.139 | Down | Decrease | Decrease | Increase |
| 7. | Acpp | -1.041 | Down | No effect | Decrease | N.T |
| 8. | Adcyap1 | -0.991 | Down | Increase | Increase | N.T |
| 9. | Grik1 | -0.903 | Down | Increase | No Effect | N.T |
| 10. | Rgs4 | -0.861 | Down | No effect | N.T | Increase |
| 11. | Galr2 | -0.740 | Down | No effect | Contradictory data | N.T |
| 12. | Kcnj5 | -0.732 | Down | Decrease | N.T | No effect |
| 13. | Plcl1 | -0.696 | Down | Decrease | Decrease | N.T |
| 14. | Gal | -0.684 | Down | Decrease | Increase | N.T |
| 15. | Nt5e | -0.680 | Down | Decrease | Decrease | Increase |
| 16. | Tac1 | -0.648 | Down | Increase | Contradictory data | Contradictory data |
| 17. | Kcnt1 | -0.639 | Down | No effect | Decrease | N.T |
| 18. | Hrh2 | -0.606 | Down | Increase | N.T | Increase |
| 19. | Gnaq | -0.605 | Down | Increase | Increase | N.T |
| 20. | Gfra2 | -0.595 | Down | Decrease | N.T | N.T |
| 21. | Ptgdr | -0.549 | Down | Decrease | N.T | N.T |
| 22. | Camk4 | -0.536 | Down | No effect | N.T | Increase |
| 23. | Ptgir | -0.509 | Down | Increase | Increase | N.T |
1These are the default functions of the specified genes. The information is gathered from the pain gene database (Lacroix-Fralish et al., 2007). N.T, not tested. Red: undesired gene response; green: desired gene response; orange: off-targets for capsaicin.