Table 2.
Pain related genes regulated by RTX.
| S.No. | Gene symbol | LogFC | Regulation | Nociception1 | Hypersensitivity1 | Analgesia1 |
|---|---|---|---|---|---|---|
| 1. | Ptgs2 | 0.685 | Up | Increase | Increase | N.T |
| 2. | S100b | 0.613 | Up | N.T | Increase | N.T |
| 3. | Spp1 | 0.550 | Up | Increase | No effect | N.T |
| 4. | Sparc | 0.545 | Up | Decrease | N.T | N.T |
| 5. | Tyrp1 | 0.543 | Up | Increase | N.T | N.T |
| 6. | Edn1 | 0.534 | Up | Decrease | Decrease | N.T |
| 7. | Iapp | -3.536 | Down | Increase | N.T | N.T |
| 8. | Trpv1 | -2.215 | Down | Increase | Increase | N.T |
| 9. | Lpar3 | -2.198 | Down | No effect | Increase | N.T |
| 10. | Adcyap1 | -1.864 | Down | Increase | Increase | N.T |
| 11. | Kcnk2 | -1.663 | Down | Decrease | Decrease | Increase |
| 12. | Gal | -1.581 | Down | Decrease | Increase | N.T |
| 13. | Tac1 | -1.503 | Down | Increase | Contradictory data | Contradictory data |
| 14. | Acpp | -1.386 | Down | No effect | Decrease#009966 | N.T |
| 15. | Grik1 | -1.318 | Down | Increase | No effect | N.T |
| 16. | Galr2 | -1.202 | Down | No effect | Contradictory data | N.T |
| 17. | Rgs4 | -1.187 | Down | No effect | N.T | Increase |
| 18. | Nt5e | -0.940 | Down | Decrease | Decrease | Increase |
| 19. | Kcnj5 | -0.919 | Down | Decrease#009966 | N.T | No effect |
| 20. | Kcnt1 | -0.904 | Down | No effect | Decrease | N.T |
| 21. | Gfra2 | -0.863 | Down | Decrease | N.T | N.T |
| 22. | Hrh2 | -0.801 | Down | Increase | N.T | Increase |
| 23. | Camk2a | -0.790 | Down | Increase | Increase | N.T |
| 24. | Scn11a | -0.712 | Down | Increase | Contradictory data | N.T |
| 25. | Adcy5 | -0.693 | Down | Increase | Increase | Increase |
| 26. | Cacna2d1 | -0.669 | Down | Increase | Increase | N.T |
| 27. | Ptgdr | -0.647 | Down | Decrease | N.T | N.T |
| 28. | Gnaq | -0.635 | Down | Increase | Increase | N.T |
| 29. | Camk4 | -0.628 | Down | No effect | N.T | Increase |
| 30. | Ucp2 | -0.617 | Down | No effect | N.T | Decrease |
| 31. | Ntrk1 | -0.567 | Down | Increase | N.T | N.T |
| 32. | Ece2 | -0.545 | Down | No effect | N.T | Increase |
| 33. | Plcl1 | -0.542 | Down | Decrease | Decrease | N.T |
| 34. | Runx1 | -0.536 | Down | Increase | Increase | N.T |
| 35. | Comt | -0.533 | Down | Decrease | N.T | Contradictory data |
| 36. | Plcb3 | -0.515 | Down | No effect | N.T | Decrease |
| 37. | Scn10a | -0.500 | Down | Decrease | Contradictory data | Decrease |
1These are the default functions of the specified genes. The information is gathered from pain gene database (Lacroix-Fralish et al., 2007). N.T, not tested. Red: undesired gene response; green: desired gene response; orange: off-targets for RTX.