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(A) UV–vis absorption spectra of DOX IN PEG-AuNPs before (black line) and after grafting of LENA (red line). (B) TEM images (scale bar: 20 and 50 nm) of DOX IN PEG-AuNPs (panel 1) and LENA@DOX IN PEG-AuNPs. (C) Normalized Raman spectra of DOX IN PEG-AuNPs before and after binding of LENA onto the nanoparticles surface. The arrows indicate those peaks that shifted following folic acid conjugation. Experimental conditions: λexc = 785 nm; laser power, 20 mW; 1200 T of 180 s.
