Table 1:
Clinical characteristics of SLE subjects with confirmed COVID-19
| Age Range | Gender | COVID-19 Dx Method | COVID-19 Symptoms | Admission | Tx for COVID-19 | Clinical manifestations of SLE/ Other Autoimmune disease | Serologies | SLE Medications | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 40s | F | RT-PCR | cough | No | HCQ, Zinc | LN, pleuritis, anemia, lymphopenia, SS | ANA, anti-dsDNA, anti-smith, anti-RNP, ACA, hypocomplementemia | Azathioprine, prednisone (5mg/day) |
| 2 | 40s | F | Rapid Antigen | SOB, diarrhea | Yes | Oxygen, Convalescent Plasma, Azithromycin | LN, neuropsychiatric lupus, APLS | ANA, anti-dsDNA, anti-SSA, ACA, hypocomplementemia | Prednisone (10mg/day), coumadin, Rituximab infusion on 2/2020 |
| 3 | 40s | F | RT-PCR | cough, fever, SOB, chest pain | Yes | Oxygen | arthritis, malar rash, pleuritis, alopecia, APLS | ANA, anti-dsDNA, anti-RNP, anti-Smith, anti-SSA, LA, ACA, anti-B2GP1, hypocomplementemia | Prednisone (6mg/day), azathioprine, HCQ, coumadin |
| 4 | 40s | F | RT-PCR | fever, chills, cough | No | Supportive care | arthritis, alopecia, LN, anemia, leukopenia, thrombocytopenia | ANA, anti-dsDNA, anti-RNP, anti-smith, anti-SSA, anti-SSB, ACA, hypocomplementemia | Prednisone (7.5mg/day), rivaroxaban (not APLS), MMF, HCQ |
| 5 | 50s | F | Rapid Antigen | headache | No | Supportive care | malar rash, photosensitivity, alopecia, LN, thrombocytopenia | ANA, anti-SSA, hypocomplementemia | Prednisone (5mg/day), Azathioprine, HCQ |
| 6 | 40s | F | RT-PCR | fever, chills, headaches, vomiting, diarrhea, loss of smell, sore throat, cough | No | Supportive care | arthritis, alopecia, photosensitivity, ITP | ANA, anti-dsDNA, LA | HCQ |
| 7 | 40s | F | Antibody | fever, cough, fatigue, myalgias, nasal congestion | No | Supportive care | malar rash, photosensitivity, alopecia, Raynaud’s, arthritis, neuropsychiatric lupus | ANA, anti-dsDNA, anti-smith, anti-RNP, anti-SSA, anti-chromatin, hypocomplementemia | MMF, HCQ |
| 8 | 40s | F | RT-PCR | cough, SOB, URI symptoms | Yes | Oxygen, Steroids, Convalescent Plasma | arthritis, Raynaud’s, photosensitivity, alopecia, oral ulcers, malar rash, SS | ANA, anti-dsDNA, anti-SSA, anti-B2GP1, hypocomplementemia | Prednisone (5mg/day), HCQ |
| 9 | 40s | F | N/A | fever, cough, fatigue, | No | Supportive care | arthritis, lymphopenia, LN | ANA, anti-dsDNA, anti-RNP, anti-smith, anti-SSA, anti-SSB, LA, ACA, anti-B2GP1, hypocomplementemia | Prednisone (20mg/day), HCQ, MMF, belimumab |
| 10 | 20s | F | RT-PCR | loss of taste and smell | No | Supportive care | malar rash, alopecia, arthritis, photosensitivity | ANA, anti-dsDNA, anti-RNP, anti-smith, anti-SSA, LA, ACA, hypocomplementemia | Prednisone (5mg/day), HCQ |
Shaded subjects had anti-interferon a autoantibodies. F=female, C=Caucasian, AA= African-America, H=Hispanic, SLE: systemic lupus erythematosus, APLS: anti-phospholipid syndrome, LN: lupus nephritis, SS: Sjögren’s syndrome, HCQ: hydroxychloroquine, MMF: mycophenolate mofetil, SOB: shortness of breath, ITP: Idiopathic thrombocytopenic purpura, BMI: Body mass index, DVT: deep vein thrombosis, PE: pulmonary embolism, HTN: hypertension, ILD: interstitial lung disease, URI: upper respiratory infection, ANA: anti-nuclear antibody, anti-dsDNA: anti-double stranded DNA, anti-SSA: anti-Sjögren’s-syndrome-related antigen A, anti-SSB: anti-Sjögren’s-syndrome-related antigen B, anti-RNP: anti-ribonucleoprotein, LA: lupus anticoagulant, ACA: anti-cardiolipin antibody, anti-B2GP1: anti-beta2 glycoprotein 1 antibody, N/A: Not available