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. 2020 Nov 11;10:19560. doi: 10.1038/s41598-020-76420-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Three-dimensional (3D) displacement vectors from a (A) MS and (B) SVD lesion demonstrating both the magnitude (red indicating a higher degree of displacement) and direction (positioning of arrows) of the displacement. Blue and red meshes represent the lesion morphology at MRI time points 2 and 1, respectively. Note the asymmetric displacement inward from time point 1 (A1, purple mesh) as indicated by mixed directional vectors along with greater differences in the magnitude of change, leading to the resulting 3D shape at time point 2 for the MS lesion (A1, grey, A2). Compare to the SVD lesion with more uniform directional vectors outward from the original lesion acquired at time point 1 (B). B1. Green mesh demonstrating evolution in lesion size and relative preservation of the original shape at MRI time point 2. B2. Displacement vectors from the SVD lesion. Note the more uniform degree of change in magnitude and direction as compared to the MS lesion.