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. 2020 Nov 11;10:19560. doi: 10.1038/s41598-020-76420-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Two-dimensional (2D) MRI axial FLAIR brain images highlighting a single SVD lesion from a 42-year-old white woman from (A) time point 1 and (B) time point 2 (1-year follow-up). Visual simulation model in 3D demonstrating displacement and deformation of the lesion at time point 2 (fluorescent green) compared to the original position at time point 1 (solid yellow). (C) Note the symmetric and more uniform growth between time points in the simulation model that is not apparent when comparing high-resolution MRI data at 3-Tesla (A,B).