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. 2020 Nov 11;10:19560. doi: 10.1038/s41598-020-76420-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Two-dimensional (2D) MRI axial FLAIR image from a patient with relapsing remitting MS with corresponding 3-dimensional (3D) simulated lesions created from two MRI time points acquired approximately 1-year apart. The yellow-mesh represents the lesion in 3D at MRI time point 1 and solid blue, representing the evolution of the lesion at MRI time point 2. Note the heterogeneity of the 3D transitions with all lesions demonstrating displacement and a few revealing reductions or increases (‘smoldering’; *) in lesion volume.