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. 2020 Nov 11;10:397. doi: 10.1038/s41398-020-01072-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Schematic displaying the overlap of executive and limbic circuit axonal fibers in the ALIC. Fibers projecting from the orbitofrontal cortex (blue) and cingulate cortex (green) are found more ventrally within the ALIC, and are associated with the limbic circuit. Fibers projecting from the dorsolateral prefrontal cortex (red), are found more dorsally in the ALIC, and are associated with the executive circuit. As demonstrated in the yellow inset box, larger lesions (lesions indicated by dotted white lines) interrupt a greater proportion of limbic fibers, but also impinge on the executive circuit. Y coordinates indicate the anterior–posterior position of each slice in Montreal Neurological Institute (MNI) space. Regions are drawn for illustrative purposes and are not to scale. b Coronal representation of lesion centroids in MNI-space, coded for clinical responders (light blue), and non-responders (red).