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. 2020 Nov 11;11(11):969. doi: 10.1038/s41419-020-03148-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A PC9GR cells were treated with indicated drugs for 24 h, and m⁶A methylation level was detected. B Western blotting analysis of m⁶A methyltransferases expression after treatment with different concentrations of β-elemene. C Predict the most likely target domain of β-elemene in METTL3 using the online PDB and PubChem database and software of AutoDock Tools. D Analysis the expression of METTL3 in cancer tissues and paired normal tissues with TCGA data. E qRT-PCR analysis of mRNA expression of autophagy-related genes after downregulation of METTL3. F Western blotting analysis of autophagy-related protein expression after downregulation of METTL3. Con, control; Ge, gefitinib; β-Ele, β-elemene; LUAD, lung adenocarcinoma; NC, negative control. The data were presented as mean ± SD. Asterisk indicates statistically significant difference (****p < 0.0001, ***p < 0.001, **p < 0.01).