Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 12;8:38. doi: 10.1038/s41413-020-00109-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Characterization of metabolically disordered OA subtypes. a Venn diagram of differentially expressed protein-coding genes (DEGs). b Heatmap of the top 10 differentially upregulated and downregulated protein-coding genes. c Violin plots showing the expression of cartilage development- and OA-related genes. d The largest functional interaction (FI) network module of differentially expressed genes between C4 and C2. e Box plot of protein expression in hydrarthrosis. f CIBERSORT-inferred relative fractions of different immune cell types across the three metabolically disordered OA subtypes. g Box plot of the relative fractions of CD8+ T cells and neutrophils in OA subtypes. (Wilcoxon rank-sum test; ^#represents FDR ≤ 0.1, ^##represents FDR ≤ 0.05, *represents FDR ≤ 0.01, and **represents FDR ≤ 0.001)