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. 2020 Nov 11;10:19570. doi: 10.1038/s41598-020-76172-5

Figure 1.

Figure 1

Structure based sequence alignment of bromelain with ananain (PDB: 6Y6L), papain (PDB: 1PPN), ervatamin B (PDB: 1IWD) and actinidin (PDB: 3P5U). Bromelain is also aligned with the three closest sequences identified in databases. The catalytic triad is highlighted in yellow, the Glu68 responsible for the bromelain specificity in light blue, amino acid difference between the database sequence and the structure in green. In the bromelain sequence, red amino acids are confirmed by MS and blue ones thanks to the electron density. Blue numbers below Cys residues indicate their disulfide bond partners.