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. 2020 Nov 11;10:19570. doi: 10.1038/s41598-020-76172-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Structures of bromelain and ananain in complex with E64 and TLCK. (a) Residues from the active site surrounding of the bromelain:E64 complex, bromelain L domain in blue and R domain in green, and E64 in yellow; H-bonds are shown as dashed lines. The feature enhanced electron density map is displayed at a 1σ level around E64. (b) Same as (a) for the ananain:E64 complex (ananain in gray sticks). (c) Superimposition of the bromelain:E64 (blue, green and yellow) and ananain:E64 (gray) complexes. (d) Same as (a) for the monomer B of the bromelain:TLCK complex. The α and β alternate conformations of TLCK are respectively represented as magenta and light pink sticks. (e) Same as (d) for the ananain:TLCK complex (ananain in gray sticks).