Table 2.

Relation of diabetes status categories (normal glucose tolerance [NGT; reference category], pre-diabetes, type 2 diabetes [T2D]), and of glycemia ascertained as hemoglobin A1c (HbA1c), with global brain amyloid level categories (low, intermediate, and high). Odds ratios (OR) were estimated with multinomial logistic regression. OR report the odds of the designated amyloid group compared to low amyloid/Model 1 is unadjusted; Model 2 is adjusted for age, sex, and APOE-ε4; Model 3 is adjusted for lipids, body mass index, and differences in medication.

		Model 1			Model 2		Model 3
	No.	Amyloid Group	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	P value
Type 2 diabetes categories
NGT	58	Intermediate	1.0		1.0		1.0
	12	High	1.0		1.0		1.0
Pre-diabetes	53	Intermediate	1.70 (0.99, 2.94)	0.056	1.92 (1.06, 3.47)	0.031	1.68 (0.91, 3.11)	0.098
	10	High	1.55 (0.61, 3.94)	0.35	1.81 (0.67, 4.91)	0.25	1.58 (0.56, 4.44)	0.38
T2D	50	Intermediate	1.08 (0.64, 1.82)	0.77	1.15 (0.65, 2.03)	0.63	1.21 (0.50, 2.95)	0.67
	6	High	0.63 (0.22, 1.78)	0.38	0.53 (0.18, 1.62)	0.27	0.90 (0.20, 4.03)	0.89
p (global)				0.24		0.11		0.55
Hemoglobin A1c (HbA1c)
HbA1c	161	Intermediate	0.96 (0.82, 1.13)	0.63	1.00 (0.84, 1.19)	0.99	1.02 (0.81, 1.28)	0.89
	28	High	0.57 (0.32, 1.01)	0.054	0.5 (0.31, 1.03)	0.062	0.59 (0.28, 1.26)	0.18
p (global)				0.15		0.17		0.37

CI = Confidence interval