Table 3.

Relation of diabetes status categories (normal glucose tolerance [NGT], pre-diabetes, type 2 diabetes [T2D]), and of glycemia ascertained as hemoglobin A1c (HbA1c), with high global brain amyloid level by the median standardized uptake value ratio (SUVR). Odds ratios (OR) and 95% confidence intervals (CI) estimated defined by multinomial logistic regression. ORs report the odds of high vs. low amyloid defined by the median SUVR. Model 1 is unadjusted; Model 2 is adjusted for age, sex, and APOE-ε4; Model 3 is adjusted for lipids, body mass index, and differences in medication. For analyses with diabetes categories, NGT is the reference category.

		Model 1		Model 2			Model 3
	High Amyloid	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)		P value
Type 2 diabetes categories
NGT	65	1.0		1.0		1.0
Pre-diabetes	58	1.57 (0.94, 2.64)	0.087	1.78 (1.01, 3.13)	0.045	1.60 (0.89, 2.86)		0.12
T2D	52	1.00 (0.61, 1.69)	0.99	1.06 (0.61, 1.84)	0.84	1.00 (0.43, 2.34)		0.99
P (global)			0.17		0.10			0.25
Hemoglobin A1c (HbA1c)
HbA1c	175	0.94 (0.80, 1.10)	0.46	0.99 (0.83, 1.18)	0.91	0.94 (0.73, 1.22)		0.66