Table 2.

Substance specific clearances (ml/min) (primary and secondary endpoints)

End-points	Time after starting treatment	n	Control arm CVVHDF†	Intervention arm CVVHD-HCO†	Mean difference‡	p value#
Myoglobin	1 h	66	3.7 [2.3, 4.7]	12.3 [10.1, 14.4]	5.5 (4.0–7.0)	< 0.0005
	6 h	65	3.4 [1.6, 3.9]	10 [8.3, 12.7]
	12 h	62	2.3 [1.5, 4]	8.3 [6.7, 10.7]
	24 h	57	1.9 [0.2, 3.1]	8.2 [6.8, 10.3]
	48 h	48	2.1 [0.1, 5.5]	6.9 [5.1, 8.8]
Urea	1 h	66	28.7 [25.6, 33.2]	24.8 [20.9, 28.7]	− 5.3 (− 8.4− (− 2.3))	0.001
	6 h	65	29.6 [25, 31.4]	25.1 [22.8, 28.3]
	12 h	62	28.8 [25.2, 32.9]	26.1 [19.8, 28.8]
	24 h	57	28.6 [25.8, 32.4]	26.7 [20.9, 29.7]
	48 h	48	31 [26.2, 32.8]	23 [20.4, 30.9]
Creatinine	1 h	66	31.4 [27.6, 35.9]	28.5 [24.7, 34.1]	4.2 (0.8–7.6)	0.015
	6 h	65	31.7 [27.2, 34.5]	29.5 [25.3, 34.9]
	12 h	62	31.1 [27.8, 34.8]	29.5 [22.5, 33]
	24 h	58	31.5 [28, 37.1]	30.4 [24.6, 35.9]
	48 h	48	32,9 [27.5, 36.5]	25.7 [23.7, 34.7]
β2− Microglobulin	1 h	66	21.1 [18, 23.8]	24.5 [19.2, 28.1]	4.4 (2.2–6.6)	< 0.0005
	6 h	65	19 [17.1, 22.4]	24.1 [21,1, 26.6]
	12 h	62	7.8 [4.5, 10.9]	22.7 [18.2, 24.5]
	24 h	57	16.4 [15.5, 19.4]	22.1 [19.2, 25.8]
	48 h	48	18 [15.5, 20.4]	21.4 [16.9, 23.7]
Interleukin− 6	1 h	66	0.2 [− 0.9, 1.2]	5 [2.4, 5.9]	1.4 (− 0.3–3.1)	0.107
	6 h	65	0.3 [− 1, 2.5]	2.5 [1, 3.5]
	12 h	62	1.2 [0, 3.7]	1.8 [0.6, 3.4]
	24 h	57	− 0.6 [− 1.3, 1.5]	1.6 [0.4, 3]
	48 h	48	0.7 [− 1.1, 4.2]	1.3 [0, 2.3]
Albumin	1 h	66	− 3.4 [− 4.2, − 1.1]	− 1.2 [− 2.6, 0.3]	− 1.1 (− 2.7–0.5)	0,170
	6 h	65	− 2.1 [− 3.5, 0.3]	− 1.4 [− 3, − 0.2]
	12 h	62	− 1.4 [− 2.9, 1.7]	− 1.7 [− 3.1, − 0.1]
	24 h	57	− 2.3 [− 4.5, − 0.8]	− 1.6 [− 3.2, − 07]
	48 h	48	− 1.7 [− 5.7, 1.2]	− 2.4 [− 5, − 0.8]

Data presented as † median [25th, 75th quantile], ‡ Estimated difference of marginal means (95% confidence interval)

ml/min milliliters per minute, CVVHDF continuous veno-venous hemodiafiltration, CVVHD-HCO continuous veno-venous hemodialysis using high cutoff filter

^#p value from comparison of marginal means