Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 11;18:429. doi: 10.1186/s12967-020-02604-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Proposed hypothetic model of NETosis as a non-canonical release mechanism of ISG15. In lupus patients, the NETs cargo is consistent with augmented amount of ISG15, which colocalized with H2B and induce the polarization of CD4, CD8 and NK to a Th1 subset that enhanced the production of IFNγ through LFA1 (CD11a/β1 integrin) (a). Low concentrations of ISG15 were found in healthy controls NETs with a diminished colocalization with H2B and reduction of Th1 IFNγ + CD4, CD8 and NK cells (b). Therefore, we proposed that ISG15 is a fingerprint of the interferogenic signature, and its release is mediated through NETosis in lupus patients