Table 2.
Results of geospatial interactive regression by selected congenital anomalies spatial error models
| Parameters | Model | ||||
|---|---|---|---|---|---|
| Parameter | Estimate (C.I.) | P-Value | Parameters | Value | P-Value |
| ADDITIVE MODELS | |||||
| spreml(log(Atrial_Septal_Defects) ~ DlyCigs11 + log(RiskAlc11) + Cannabis) | |||||
| Atrial Septal Defect | |||||
| Cannabis | 0.03 (0.00, 0.06) | 0.0305 | phi | 1.01E-02 | NA |
| psi | −3.13E-06 | 0.9999 | |||
| rho | −7.64E-01 | 0.9400 | |||
| CHROMOSOMAL Defects | |||||
| Cannabis | 0.04 (0.01, 0.07) | 0.0212 | phi | 1.05E-02 | NA |
| psi | 2.99E-06 | 1 | |||
| rho | −4.66E-01 | 0.2291 | |||
| Downs Syndrome | |||||
| Cannabis | 0.09 (0.05, 0.13) | 2.9E-05 | phi | 5.57E-02 | NA |
| Binge_Alcohol | −2.02 (−3.35, − 0.69) | 0.0029 | psi | 3.57E-05 | 0.9999 |
| rho | −6.85E-01 | 0.0883 | |||
| Gastroschisis | |||||
| Cannabis | 0.07 (0.03, 0.11) | 0.0030 | phi | 1.44E-02 | NA |
| psi | 1.78E-05 | 0.9999 | |||
| rho | −2.50E-01 | 0.552 | |||
| Hypospadias | |||||
| Cannabis | −0.07 (−0.13, −0.01) | 0.0166 | phi | 0.0419 | 0.9972 |
| psi | 3.0E-05 | 0.9999 | |||
| rho | −0.6292 | 0.1224 | |||
| Patent Ductus Arteriosus | |||||
| Cannabis | 0.03 (0.01, 0.05) | 0.0453 | phi | 1.01E-02 | NA |
| psi | −9.20E-06 | 1.0000 | |||
| rho | −1.0E+ 00 | 0.0025 | |||
| Small Intestinal Stenosis / Atresia | |||||
| Cannabis | 0.07 (0.03, 0.11) | 0.0001 | phi | 1.09E-02 | NA |
| psi | 6.74E-05 | 0.9998 | |||
| rho | −1.15E-02 | 0.9776 | |||
| Tetralogy Fallot | |||||
| Cannabis | 0.09 (0.04, 0.14) | 0.0007 | phi | 1.10E-01 | 0.9963 |
| psi | 5.67E-05 | 0.9998 | |||
| rho | 3.07E-01 | 0.3382 | |||
| INTERACTIVE MODELS | |||||
| spreml(Atrial_Septal_Defects ~ Tobacco * Binge_Alcohol * Cannabis) | |||||
| Atrial_Septal_Defect | |||||
| Binge_Alcohol: Cannabis | −0.58 (−1.12, − 0.04) | 0.0376 | phi | 0.0101 | NA |
| Tobacco: Binge_Alcohol: Cannabis | 0.03 (0, 0.06) | 0.0417 | psi | 9.1E-08 | 1.0000 |
| Tobacco: Cannabis | −0.09 (− 0.18, 0) | 0.0423 | rho | −0.9960 | 0.0037 |
| CHROMOSOMAL_Defects | |||||
| Tobacco: Binge_Alcohol: Cannabis | −0.01 (− 0.01, − 0.01) | 0.0007 | phi | 0.0890 | NA |
| Binge_Alcohol: Cannabis | 0.05 (0.02, 0.08) | 0.0021 | psi | 2.2E-05 | 0.9999 |
| Tobacco: Cannabis | 0.02 (0.01, 0.03) | 0.0047 | rho | −0.9805 | 0.0058 |
| Tobacco: Binge_Alcohol | 0.02 (0, 0.04) | 0.0184 | |||
| Diaphragmatic_Hernia | |||||
| Cannabis | 7.26 (3.21, 11.31) | 0.0004 | phi | 0.0095 | 0.9964 |
| Binge_Alcohol | 7.33 (3.15, 11.51) | 0.0006 | psi | −1.7E-07 | 1.0000 |
| Binge_Alcohol: Cannabis | −2.07 (−3.26, − 0.88) | 0.0006 | rho | 0.9660 | <2e-16 |
| Tobacco: Cannabis | −0.22 (− 0.37, − 0.07) | 0.0041 | |||
| Tobacco: Binge_Alcohol: Cannabis | 0.06 (0.02, 0.1) | 0.0051 | |||
| Tobacco | 0.17 (0.04, 0.3) | 0.0091 | |||
| Downs Syndrome | |||||
| Binge_Alcohol: Cannabis | 0.03 (0.02, 0.04) | 3.4E-05 | phi | 0.0571 | NA |
| Binge_Alcohol | −2.33 (−3.7, −0.96) | 0.0008 | psi | 3.6E-05 | 0.9998 |
| rho | −0.6662 | 0.0626 | |||
| Gastroschisis | |||||
| Cannabis | 0.07 (0.03, 0.11) | 0.0030 | phi | 0.0144 | NA |
| psi | 1.8E-05 | 0.9999 | |||
| rho | −0.2503 | 0.5520 | |||
| Hypospadias | |||||
| Tobacco: Cannabis | −0.13 (− 0.22, − 0.04) | 0.0062 | phi | 0.0027 | NA |
| Tobacco: Binge_Alcohol: Cannabis | 0.04 (0.01, 0.07) | 0.0084 | psi | 4.3E-05 | 0.9999 |
| Tobacco: Binge_Alcohol | −0.35 (− 0.66, − 0.04) | 0.0266 | rho | −0.2080 | 0.6705 |
| Tobacco | 1.13 (0.11, 2.15) | 0.0304 | |||
| Patent_Ductus_Arteriosus | |||||
| Cannabis | 0.24 (0.01, 0.47) | 0.0358 | phi | 0.0109 | NA |
| Binge_Alcohol: Cannabis | −0.06 (−0.12, 0) | 0.0526 | psi | 1.8E-06 | 1.0000 |
| rho | −0.9998 | 0.0022 | |||
| Small Intestinal Stenosis / Atresia | |||||
| Cannabis | 0.02 (0.01, 0.03) | 0.0003 | phi | 0.0100 | NA |
| psi | 1.3E-07 | 1.0000 | |||
| rho | −0.0089 | 0.9825 | |||
| Tetralogy_Fallot | |||||
| Cannabis | 0.09 (0.04, 0.14) | 0.0007 | phi | 0.1102 | 0.9963 |
| psi | 5.7E-05 | 0.9998 | |||
| rho | 0.3074 | 0.3382 | |||
| Ventricular_Septal_Defect | |||||
| Tobacco: Cannabis | −0.11 (− 0.21, − 0.01) | 0.0328 | phi | 0.4947 | NA |
| Tobacco: Binge_Alcohol: Cannabis | 0.03 (0, 0.06) | 0.0372 | psi | 1.2E-04 | 0.9997 |
| Cannabis | 2.93 (− 0.23, 6.09) | 0.0692 | rho | −1.0000 | 0.0306 |
| Binge_Alcohol: Cannabis | −0.85 (−1.79, 0.09) | 0.0750 | |||
Technical Abbreviations: phi Idiosyncratic component of the spatial error termpsi: individual time-invariant component of the spatial error termrho: spatial autoregressive parameter, lambda: spatial autocorrelation coefficient