Table 6.
Robust generalized linear regression models
| Parameter | Estimate (95%C.I.) | P-Value |
|---|---|---|
| PC1 | ||
| Cannabis | 3.46 (0.58, 6.34) | 0.0382 |
| Cigarettes: Alcohol | 0.45 (0.04, 0.85) | 0.0521 |
| Cigarettes | −1.52 (−2.89, − 0.16) | 0.0510 |
| Alcohol: Cannabis | −1 (−1.82, − 0.17) | 0.0369 |
| PC1 as Arcsinh | ||
| Cannabis | 2.89 (0.87, 4.92) | 0.0172 |
| Cigarettes: Alcohol | 0.39 (0.11, 0.67) | 0.0212 |
| Cigarettes | −1.31 (−2.26, − 0.36) | 0.0204 |
| Alcohol: Cannabis | −0.85 (− 1.43, − 0.26) | 0.0162 |
| Central Nervous System | ||
| Anencephalus | ||
| Cigarettes: Cannabis | 0.1 (0.04, 0.16) | 0.0065 |
| Cigarettes: Alcohol | 0.55 (0.1, 1) | 0.0384 |
| Cigarettes | −1.81 (−3.32, − 0.31) | 0.0399 |
| Cigarettes: Alcohol: Cannabis | −0.03 (− 0.05, − 0.01) | 0.0068 |
| CNO | ||
| Alcohol | 2.8 (0.84, 4.76) | 0.0189 |
| Cannabis | 2.6 (1.06, 4.14) | 0.0078 |
| Cigarettes: Alcohol: Cannabis | 0.02 (0.01, 0.04) | 0.0156 |
| Cigarettes: Cannabis | −0.08 (− 0.14, − 0.02) | 0.0194 |
| Alcohol: Cannabis | − 0.79 (−1.25, − 0.34) | 0.0067 |
| Cardiovascular System | ||
| ASD | ||
| Cigarettes: Alcohol: Cannabis | 0.12 (0.06, 0.18) | 0.0051 |
| Cannabis | 8.4 (3.93, 12.88) | 0.0062 |
| Alcohol | 21.3 (8.16, 34.43) | 0.0130 |
| Cigarettes | 3.48 (1.07, 5.89) | 0.0223 |
| Cigarettes: Alcohol | −1.05 (− 1.78, −0.32) | 0.0227 |
| Alcohol: Cannabis | −2.5 (−3.8, −1.19) | 0.0056 |
| Cigarettes: Cannabis | −0.4 (− 0.61, − 0.19) | 0.0055 |
| VSD | ||
| Cigarettes: Alcohol: Cannabis | 0.04 (0.01, 0.07) | 0.0242 |
| Cannabis | 3.38 (0.63, 6.13) | 0.0366 |
| Alcohol: Cannabis | −0.98 (−1.79, − 0.18) | 0.0381 |
| Cigarettes: Cannabis | −0.13 (− 0.23, − 0.03) | 0.0239 |
| PDA | ||
| Cannabis | 6.68 (1.28, 12.07) | 0.0416 |
| Cigarettes: Alcohol: Cannabis | 0.09 (0.01, 0.16) | 0.0504 |
| Alcohol | 16.71 (0.91, 32.5) | 0.0719 |
| Cigarettes: Cannabis | −0.29 (− 0.53, − 0.04) | 0.0536 |
| Alcohol: Cannabis | −1.98 (−3.55, − 0.4) | 0.0392 |
| Tetralogy Fallot | ||
| Cannabis | 0.08 (0.01, 0.15) | 0.0410 |
| Gastrointestinal System | ||
| Cigarettes: Alcohol: Cannabis | 0.02 (0.01, 0.03) | 0.0031 |
| Cigarettes | 0.7 (0.27, 1.13) | 0.0090 |
| Cigarettes: Alcohol | −0.22 (−0.35, − 0.09) | 0.0081 |
| Cigarettes: Cannabis | −0.07 (− 0.11, − 0.04) | 0.0029 |
| Small Intestinal Stenosis or Atresia - Additive | ||
| Cannabis | 0.043 (0.004, 0.081) | 0.0463 |
| Small Intestinal Stenosis or Atresia - IR | ||
| Cigarettes: Cannabis | 0.002 (0, 0.005) | 0.0692 |
| Genitourinary System | ||
| Cigarettes: Alcohol: Cannabis | 0.01 (0, 0.01) | 0.0113 |
| Cigarettes | 0.28 (0.08, 0.48) | 0.0199 |
| Cigarettes: Alcohol | −0.09 (− 0.15, − 0.02) | 0.0195 |
| Cigarettes: Cannabis | − 0.03 (− 0.04, − 0.01) | 0.0103 |
| Renal Pelvis Obstruction | ||
| Alcohol: Cannabis | 0.65 (0.1, 1.21) | 0.0425 |
| Cigarettes: Cannabis | 0.08 (0, 0.15) | 0.0656 |
| Cigarettes: Alcohol: Cannabis | −0.02 (− 0.04, 0) | 0.0614 |
| Cannabis | −2.17 (−4.03, − 0.31) | 0.0450 |
| Chromosomal Anomalies | ||
| Alcohol: Cannabis | 0.02 (0, 0.05) | 0.0678 |
| Alcohol | −0.82 (−1.62, − 0.02) | 0.0684 |
| GIT | ||
| Cigarettes: Cannabis | 0.04 (0.01, 0.08) | 0.0380 |
| Cigarettes: Alcohol | 0.34 (−0.01, 0.68) | 0.0878 |
| Cigarettes | −1.07 (−2.17, 0.02) | 0.0862 |
| Cigarettes: Alcohol: Cannabis | −0.01 (− 0.03, 0) | 0.0357 |
| Respiratory | ||
| Cigarettes: Cannabis | 0.01 (0, 0.02) | 0.0927 |
| Cigarettes: Alcohol: Cannabis | 0 (−0.01, 0) | 0.0497 |
| Downs - Additive | ||
| Cannabis | 0.04 (0.01, 0.07) | 0.0186 |
| Alcohol | −1.29 (−2.43, − 0.15) | 0.0464 |
| Downs - Interactive | ||
| Cigarettes | 0.21 (0.01, 0.41) | 0.0599 |
| Cigarettes: Alcohol | −0.07 (− 0.13, − 0.01) | 0.0441 |
| Cigarettes: Alcohol: Cannabis | 0.0007 (0.0002, 0.0013) | 0.0198 |
| Body Wall | ||
| Musculoskeletal | ||
| Cannabis | 2.71 (0.93, 4.49) | 0.0123 |
| Cigarettes: Cannabis | −0.13 (− 0.22, − 0.05) | 0.0113 |
| Alcohol: Cannabis | − 0.8 (−1.32, − 0.27) | 0.0130 |
| Cigarettes: Alcohol: Cannabis | 0.04 (0.01, 0.06) | 0.0118 |
| Gastroschisis | ||
| Cigarettes | 0.11 (0, 0.21) | 0.0684 |
| Cannabis | 0.27 (0, 0.53) | 0.0705 |
| Cigarettes: Cannabis | −0.01 (−0.02, 0) | 0.0920 |
| Exomphalos | ||
| Cigarettes: Cannabis | 0.1 (0.04, 0.16) | 0.0118 |
| Cannabis | 0.56 (0.14, 0.98) | 0.0289 |
| Cigarettes: Alcohol | 1.03 (0.21, 1.85) | 0.0357 |
| Alcohol | −12.72 (−24.65, −0.8) | 0.0661 |
| Cigarettes | −3.2 (−5.78, − 0.61) | 0.0386 |
| Cigarettes: Alcohol: Cannabis | −0.04 (− 0.06, − 0.02) | 0.0093 |
| Face | ||
| Cleft Palate / Lip | ||
| Cannabis | 0.57 (0.22, 0.92) | 0.0092 |
| Cigarettes: Alcohol | 0.04 (0, 0.07) | 0.0467 |
| Alcohol: Cannabis | −0.12 (−0.2, − 0.04) | 0.0128 |