Table 8.
E-values for key regression parameters
| Parameter | Table | Estimate (95%C.I.) | RR | E-Values |
|---|---|---|---|---|
| Mixed Effects Models | ||||
| lme(Congenital_Anomaly ~ Tobacco * Binge_Alcohol * Cannabis) | ||||
| Cardiovascular Anomalies | ||||
| Atrial_Septal_Defect | ||||
| Cannabis | Table 7 | 0.053 (0.011, 0.096) | 1.15 (1.03, 1.29) | 1.57, 1.20 |
| Tetralogy of Fallot | ||||
| Cannabis | Table 7 | 0.079 (0.024, 0.133) | 1.18 (1.05, 1.32) | 1.63, 1.29 |
| Gastrointestinal Tract Anomalies | ||||
| Cigarettes: Alcohol: Cannabis | Table 7 | 0.022 (0.004, 0.041) | 1.3E+ 160 (3.5E+ 30, 5.1E+ 289) | Infinity, 6.9E+ 30 |
| Small_Intestinal_Stenosis_Atresia | ||||
| Alcohol: Cannabis | Table 7 | 0.02 (0.008, 0.032) | 1.05 (1.02, 1.09) | 1.29, 1.16 |
| Genitourinary Tract Anomalies | ||||
| Cigarettes: Alcohol: Cannabis | Table 7 | 0.008 (0.002, 0.014) | Infinity (6.9E+ 169, Infinity) | Infinity, Infinity |
| Chromosomal Anomalies | ||||
| Cannabis | Table 7 | 0.084 (0.019, 0.149) | 1.32 (1.06, 1.64) | 1.97, 1.33 |
| Downs_Syndrome | ||||
| Cigarettes: Alcohol: Cannabis | Table 7 | 0.001 (0, 0.001) | 1.002 (1.000, 1.004) | 1.048, 1.009 |
| Body Wall Anomalies | ||||
| Musculoskeletal | ||||
| Cannabis | Table 7 | 2.686 (0.671, 4.701) | Inf (Inf, Inf) | Infinity, Infinity |
| Gastroschisis | ||||
| Cannabis | Table 7 | 0.065 (0.016, 0.115) | 1.16 (1.04, 1.30) | 1.59, 1.24 |
| Exomphalos | ||||
| Alcohol: Cannabis | Table 7 | 0.042 (0.002, 0.082) | 1.07 (1.0045, 1.15) | 1.36, 1.07 |
| Geospatial Models | ||||
| spreml(Congenital_Anomaly ~ Tobacco * Binge_Alcohol * Cannabis) | ||||
| Atrial_Septal_Defect | ||||
| Binge_Alcohol: Cannabis | Table 1 | −0.58 (−1.12,-0.03) | 0.11 (0.13, 0.87) | 17.99, 1.54 |
| Tobacco: Binge_Alcohol: Cannabis | Table 1 | 0.03 (0,0.05) | 1.11 (1.00, 1.22) | 1.45, 1.07 |
| Tobacco: Cannabis | Table 1 | −0.09 (− 0.18,0) | 0.71 (0.51, 0.99) | 2.17, 1.12 |
| Tetralogy_Fallot | ||||
| Cannabis | Table 1 | 0.09 (0.04,0.14) | 1.21 (1.08, 1.37) | 1.73, 1.39 |
| Ventricular_Septal_Defect | ||||
| Tobacco: Cannabis | Table 1 | −0.11 (− 0.21,− 0.01) | 0.57 (0.34, 0.95) | 2.90, 1.27 |
| Tobacco: Binge_Alcohol: Cannabis | Table 1 | 0.03 (0,0.06) | 1.17 (1.01, 1.37) | 1.63, 1.11 |
| Patent_Ductus_Arteriosus | ||||
| Cannabis | Table 1 | 0.24 (0.02,0.47) | 2.63 (1.06, 6.51) | 4.71, 1.34 |
| Chromosomal_Defects | ||||
| Tobacco: Binge_Alcohol: Cannabis | Table 1 | -0.01 (− 0.01,0) | 0.97 (0.95, 0.99) | 1.21, 1.13 |
| Binge_Alcohol: Cannabis | Table 1 | 0.05 (0.02,0.09) | 1.28 (1.09, 1.50) | 1.88, 1.42 |
| Tobacco: Cannabis | Table 1 | 0.02 (0,0.03) | 1.07 (1.02, 1.12) | 1.35, 1.16 |
| Downs Syndrome | ||||
| Binge_Alcohol: Cannabis | Table 1 | 0.03 (0.01,0.04) | 1.06 (1.03, 1.10) | 1.33, 1.22 |
| Small Intestinal Stenosis / Atresia | ||||
| Cannabis | Table 1 | 0.02 (0.01,0.03) | 1.06 (1.03, 1.10) | 1.31, 1.19 |
| Diaphragmatic_Hernia | ||||
| Cannabis | Table 1 | 7.26 (3.21,11.31) | 2.09E+ 09 (1.34E+ 04, 3.27E+ 14) | 4.19E+ 09, 2.69E+ 04 |
| Binge_Alcohol: Cannabis | Table 1 | −2.07 (− 3.25,-0.88) | 2.21E-03 (6.67E-05, 0.74) | 9.00E+ 02, 26.56 |
| Tobacco: Cannabis | Table 1 | −0.22 (− 0.38,-0.07) | 0.52 (0.33, 0.81) | 3.28, 1.77 |
| Tobacco: Binge_Alcohol: Cannabis | Table 1 | 0.06 (0.02,0.11) | 1.20 (1.05, 1.36) | 1.69, 1.30 |
| Gastroschisis | ||||
| Cannabis | Table 1 | 0.07 (0.02,0.11) | 1.17 (1.06, 1.31) | 1.63, 1.30 |