Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 11;20:1093. doi: 10.1186/s12885-020-07569-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Cancer Outlier Profile Analysis (COPA) of BRF2 in breast cancer. Outlier analysis was performed to identify if BRF2 is an outlier in a subset of breast cancer samples using BRF2 gene expression data in Oncomine [21]. a Outlier analysis results for BRF2 in breast cancer using threshold p-value 1E-8, fold change of 20, and gene rank of top 1%. Outlier analysis of 1992 samples from the Curtis Breast 2 [27] and 1602 samples from the TCGA Breast 2 data sets [28, 34, 35] was performed for (b) BRF2 and (c) ERBB2 (HER2) to determine median gene rank and COPA score. (d) Comparison of fold-change in expression of BRF2 and a subset of known biomarkers in breast cancer using the TCGA Breast Cancer Data set [28], n = 593 samples. The data sets analyzed during the current study are available at www.oncomine.org. Queries of Oncomine were performed in September 2019, October 2019, November 2019, January 2020, February 2020, and March 2020