Table 1.
Clinicopathological features and risk factor of recurrence in 200 primary hepatocellular carcinomas (HCC)
| Clinicopathologic factors | Primary HCC | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| (n = 200) | χ 2 | P–value | χ 2 | P–value | |
| Age (years, mean ± SD) | 64.8 ± 10.8 | 0.537 | 0.464 | ||
| Gender (male/female) | 154/45 | 0.178 | 0.673 | ||
| Viral infection (HBV/HCV/NBNC) | 43/99/57 | 3.386 | 0.184 | ||
| Child‐Pugh classification (A/B/C) | 146/51/3 | 3.322 | 0.073 | ||
| AST (IU/L, mean ± SD) | 54.12 ± 33.8 | 11.30 | 0.001 | 8.524 | 0.004 |
| ALT (IU/L, mean ± SD) | 49.92 ± 38.9 | 1.191 | 0.275 | ||
| Plt (×109/L, mean ± SD) | 15.57 ± 8.7 | 1.680 | 0.195 | ||
| ICG‐R15 (%, mean ± SD) | 19.02 ± 11.4 | 1.047 | 0.306 | ||
| PT% (mean ± SD) | 84.89 ± 14.3 | 8.620 | 0.003 | 1.564 | 0.211 |
| T.bil (mg/dL, mean ± SD) | 0.94 ± 0.76 | 0.449 | 0.503 | ||
| Alb (g/dL, mean ± SD) | 3.86 ± 0.54 | 5.038 | 0.025 | 0.826 | 0.364 |
| AFP (ng/mL) ≥ 100 vs < 100 | 65/135 | 9.933 | 0.002 | 5.154 | 0.023 |
| PIVKA‐II (mAU/mL) ≥ 100 vs < 100 | 102/98 | 2.629 | 0.105 | ||
| Tumor max size (mean ± SD) | 5.06 ± 3.7 | 4.154 | 0.042 | 2.892 | 0.089 |
| Solitary or multiple | 136/64 | 0.498 | 0.481 | ||
| Capsular formation (pfc) (−/+) | 45/155 | 0.512 | 0.474 | ||
| Capsular invasion (pfc‐inf) (−/+) | 81/119 | 0.014 | 0.907 | ||
| Portal vein invasion (pvp) (−/+) | 102/98 | 7.312 | 0.007 | 0.034 | 0.854 |
| Macro vascular invasion (vp0–1/vp > 2) | 159/41 | 16.709 | <0.001 | 5.338 | 0.021 |
| Hepatic vein invasion (pvv) (−/+) | 171/29 | 6.260 | 0.012 | 1.624 | 0.225 |
| Stages (I/II/III/IV) | 14/87/66/52 | 8.048 | 0.005 | 0.648 | 0.421 |
| Background of liver (CH/LC/NL) | 87/102/11 | 1.689 | 0.430 | ||
| Degree of differention (well/mod/poor) | 49/115/36 | 7.982 | 0.019 | 0.542 | 0.762 |
AFP, α‐fetoprotein; Alb, albumin; ALT, alanine aminotransferase; AST, aspartate amino transferase; CH, chronic hepatitis; ICG‐R15, indocyanine green retention rate at 15 min; LC, cirrhosis; NL, normal liver; PIVKAII, protein induced by vitamin K absence or antagonists II; PLT, platelet; PT%, prothrombin time; T.bil, total bilirubin; +, positive; −, negative.