Table 4.
Univariate and multivariate analyses of early recurrence
| Clinicopathologic factors | Early recurrence (n = 29) | Late recurrence (n = 24) | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate (HR, 95% CI) | P‐value | Multivariate (HR, 95% CI) | P‐value | Univariate (HR 95% CI) | P‐value | Multivariate (HR, 95% CI) | P‐value | |
| Age | 0.954 (0.919–0.990) | 0.012 | 0.965 (0.900–1.034) | 0.307 | 0.966(0.925–1.010) | 0.125 | ||
|
Gender (female versus male) |
1.051 (0.421–2.627) | 0.915 | 1.408 (0.498–3.985) | 0.519 | ||||
| Viral infection | 0.025 | 0.938 | 0.218 | |||||
| NBNC | NA | NA | NA | |||||
| HBV | 5.339 (1.522–18.728) | 0.922 (0.103–8.251) | 2.629 (0.784–8.815) | |||||
| HCV | 1.276 (0.521–3.126) | 0.815 (0.260–2.558) | 2.212 (0.803–6.095) | |||||
| AST | 0.999 (0.989–1.009) | 0.854 | 1.004 (0.989–1.019) | 0.622 | ||||
| ALT | 0.993 (0.981–1.004) | 0.210 | 1.004 (0.997–1.011) | 0.245 | ||||
| Plt | 0.983 (0.929–1.039) | 0.540 | 0.947 (0.897–1.004) | 0.068 | ||||
| ICG‐R15 | 1.014 (0.983–1.045) | 0.388 | 1.005 (0.961–1.051) | 0.835 | ||||
| PT% | 0.962 (0.932–0.992) | 0.015 | 0.971 (0.933–1.011) | 0.151 | 0.998 (0.980–1.016) | 0.798 | ||
| T.bil | 2.069 (0.858–4.985) | 0.105 | 3.082 (1.112–8.543) | 0.030 | 4.580 (1.202–17.46) | 0.026 | ||
| Alb | 1.409 (0.491–4.046) | 0.524 | 1.543 (0.475–5.018) | 0.471 | ||||
|
AFP, ng/mL ≥100 vs < 100) |
0.580 (0.271–1.240) | 0.160 | 0.467 (0.148–1.475) | 0.194 | ||||
|
PIVKA‐II, mAU/mL (≥100 vs < 100) |
0.778 (0.361–1.677) | 0.522 | 0.875 (0.363–2.108) | 0.765 | ||||
|
Tumor max size (≥5.0 vs < 5.0) |
0.921 (0.427–1.985) | 0.833 | 3.588 (1.164–11.06) | 0.026 | 3.932 (1.205–12.83) | 0.023 | ||
|
Number of tumors (multiple versus solitary) |
1.153 (0.502–2.650) | 0.738 | 1.143 (0.480–2.718) | 0.763 | ||||
| Capsular invasion | 0.802 (0.361–1.784) | 0.589 | 0.849 (0.368–1.957) | 0.700 | ||||
| Portal vein invasion | 0.535 (0.247–1.158) | 0.112 | 1.965 (0.808–4.781) | 0.137 | ||||
| Hepatic vein invasion | 0.323 (0.124–0.846) | 0.022 | 0.357 (0.129–0.987) | 0.047 | 1.223 (0.359–4.174) | 0.748 | ||
| Vascular invasion | 0.486 (0.215–1.095) | 0.082 | 1.965 (0.808–4.781) | 0.137 | ||||
| Stages (I + II versus III + IV) | 0.526 (0.233–1.187) | 0.122 | 1.549 (0.635–3.778) | 0.336 | ||||
| VIL1 mRNA expression | 1.145 (1.008–1.301) | 0.037 | 1.164 (1.016–1.333) | 0.028 | 0.882 (0.767–1.014) | 0.079 | ||
AFP, α‐fetoprotein; Alb, albumin; ALT, alanine aminotransferase; AST, aspartate amino transferase; ICG‐R15, indocyanine green retention rate at 15 min; PIVKAII, protein induced by vitamin K absence or antagonists II; PLT, platelet; PT%, prothrombin time; T.bil, total bilirubin.